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Proceedings Papers

Modeling the Dynamic Composition of Engineered Cartilage

Christopher G. Wilson, Sean S. Kohles, Lawrence J. Bonassar
Proc. ASME. IMECE2001, Advances in Bioengineering, 15-16, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23007
https://doi.org/10.1115/IMECE2001/BED-23007
View Paper titled, Modeling the Dynamic Composition of Engineered Cartilage
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Topics: Cartilage, Modeling, Biological tissues, Polymers
Proceedings Papers

Analysis of Bending Behavior of Native Auricular and Costal Cartilage and Tissue Engineered Constructs

Rani Roy, Sean S. Kohles, Victor Zaporojan, Lawrence Bonassar
Proc. ASME. IMECE2001, Advances in Bioengineering, 19-20, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23009
https://doi.org/10.1115/IMECE2001/BED-23009
View Paper titled, Analysis of Bending Behavior of Native Auricular and Costal Cartilage and Tissue Engineered Constructs
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Topics: Biological tissues, Cartilage, Deflection, Deformation, Elastic moduli, Elasticity, Mechanical properties, Soft tissues
Journal Articles

Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation

Shelley S. Mason, Sean S. Kohles, Randy D. Zelick, Shelley R. Winn, Asit K. Saha
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Design Innovation Paper
J. Nanotechnol. Eng. Med. May 2011, 2(2): 025001.
https://doi.org/10.1115/1.4003878
Published Online: May 19, 2011
View Article titled, Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation
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Topics: Biological tissues, Biomaterials, Bioreactors, Cartilage, Chondrocytes
Journal Articles

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Asit K. Saha, Yu Liang, Sean S. Kohles
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. May 2011, 2(2): 021004.
https://doi.org/10.1115/1.4003876
Published Online: May 13, 2011
View Article titled, Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis
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Topics: Biological tissues, Cartilage, Chondrocytes, Diseases, Musculoskeletal system, Stress, Theorems (Mathematics), Simulation, Dynamics (Mechanics), Differential equations
Proceedings Papers

Modeling Nanomechanical Strains in Healthy and Diseased Single-Cells Due to Applied Fluidic Stresses

Zachary D. Wilson, Sean S. Kohles
Proc. ASME. NEMB2010, ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology, 325-327, February 7–10, 2010
Publisher: American Society of Mechanical Engineers
Paper No: NEMB2010-13010
https://doi.org/10.1115/NEMB2010-13010
View Paper titled, Modeling Nanomechanical Strains in Healthy and Diseased Single-Cells Due to Applied Fluidic Stresses
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Topics: Modeling, Stress, Flow (Dynamics), Microfluidics, Resolution (Optics), Biology, Biomechanics, Cellular mechanics, Chondrocytes, Diseases
Journal Articles

Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells

Sean S. Kohles, Yu Liang, Asit K. Saha
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. January 2011, 133(1): 011004.
https://doi.org/10.1115/1.4002939
Published Online: December 22, 2010
View Article titled, Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells
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Topics: Biological cells, Biomechanics, Stress, Microfluidics, Flow (Dynamics)
Journal Articles

A Multivariate Logistical Model for Identifying the Compressive Sensitivity of Single Rat Tactile Receptors as Nanobiosensors

Sean S. Kohles, Sam Bradshaw, Shelley S. Mason, Fred J. Looft
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. February 2011, 2(1): 011002.
https://doi.org/10.1115/1.4002750
Published Online: December 13, 2010
View Article titled, A Multivariate Logistical Model for Identifying the Compressive Sensitivity of Single Rat Tactile Receptors as Nanobiosensors
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Topics: Biosensors, Modeling, Skin, Stress, Nanoscale phenomena, Compressive stress
Journal Articles

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

Asit K. Saha, Sean S. Kohles
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. November 2010, 1(4): 041001.
https://doi.org/10.1115/1.4002461
Published Online: October 21, 2010
View Article titled, Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis
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Topics: Biological tissues, Biomechanics, Cartilage, Chondrocytes, Steady state, Stress, Dynamics (Mechanics), Nanoscale phenomena, Modeling
Journal Articles

A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model

Asit K. Saha, Sean S. Kohles
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. August 2010, 1(3): 031005.
https://doi.org/10.1115/1.4001934
Published Online: August 10, 2010
View Article titled, A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model
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Topics: Cartilage, Microfluidics, Nanoscale phenomena, Stress, Steady state, Biology, Simulation, Biological tissues, Dynamics (Mechanics)
Journal Articles

Two-Dimensional Modeling of Nanomechanical Strains in Healthy and Diseased Single-Cells During Microfluidic Stress Applications

Zachary D. Wilson, Sean S. Kohles
Journal: Journal of Nanotechnology in Engineering and Medicine
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. May 2010, 1(2): 021005.
https://doi.org/10.1115/1.4001309
Published Online: May 5, 2010
View Article titled, Two-Dimensional Modeling of Nanomechanical Strains in Healthy and Diseased Single-Cells During Microfluidic Stress Applications
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Topics: Flow (Dynamics), Microfluidics, Stress
Journal Articles

Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations

Sean S. Kohles, Nathalie Nève, Jeremiah D. Zimmerman, Derek C. Tretheway
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. December 2009, 131(12): 121006.
https://doi.org/10.1115/1.4000121
Published Online: November 10, 2009
View Article titled, Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations
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Topics: Flow (Dynamics), Fluids, Stress, Gravity (Force), Microfluidics, Shear (Mechanics), Microchannel flow
Proceedings Papers

Exploring Microscale Phenomena With the µPIVOT (µPIV and Optical Tweezers)

Derek C. Tretheway, Nathalie Ne`ve, Sean S. Kohles
Proc. ASME. IMECE2008, Volume 13: Nano-Manufacturing Technology; and Micro and Nano Systems, Parts A and B, 971-973, October 31–November 6, 2008
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2008-67901
https://doi.org/10.1115/IMECE2008-67901
View Paper titled, Exploring Microscale Phenomena With the µPIVOT (µPIV and Optical Tweezers)
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Topics: Fluid-dynamic forces, Fluids, Microscale devices, Non-Newtonian fluids, Particulate matter, Rheology, Theoretical analysis
Proceedings Papers

An Integrated Micron-Resolution Particle Image Velocimeter/Optical Tweezers (μPIVOT) for Microenvironment Investigations

James K. Lingwood, Nathalie Ne`ve, Sean S. Kohles, Derek C. Tretheway
Proc. ASME. IMECE2007, Volume 11: Micro and Nano Systems, Parts A and B, 835-837, November 11–15, 2007
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2007-41996
https://doi.org/10.1115/IMECE2007-41996
View Paper titled, An Integrated Micron-Resolution Particle Image Velocimeter/Optical Tweezers (μPIVOT) for Microenvironment Investigations
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Topics: Particulate matter, Resolution (Optics), Velocimeters, Microscale devices, Cellular mechanics, Flow (Dynamics), Hydrodynamics, Instrumentation, Lasers, Non-Newtonian fluids
Proceedings Papers

Microfluidics Supporting an Optical Instrument for Multimodal Single Cell Biomechanics

Nathalie Ne`ve, James K. Lingwood, Shelley R. Winn, Derek C. Tretheway, Sean S. Kohles
Proc. ASME. IMECE2007, Volume 11: Micro and Nano Systems, Parts A and B, 839-841, November 11–15, 2007
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2007-42004
https://doi.org/10.1115/IMECE2007-42004
View Paper titled, Microfluidics Supporting an Optical Instrument for Multimodal Single Cell Biomechanics
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Topics: Cellular mechanics, Microfluidics, Optical instruments, Stress, Biomechanics, Compression, Deformation, Fluids, Hydrostatic pressure, Particulate matter
Journal Articles

A Mechanical Composite Spheres Analysis of Engineered Cartilage Dynamics

Sean S. Kohles, Christopher G. Wilson, Lawrence J. Bonassar
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. August 2007, 129(4): 473–480.
https://doi.org/10.1115/1.2746366
Published Online: November 22, 2006
View Article titled, A Mechanical Composite Spheres Analysis of Engineered Cartilage Dynamics
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Topics: Cartilage, Composite materials, Biological tissues, Biomechanics, Elasticity, Chondrocytes, Polymers
Journal Articles

A First-Order Mechanical Device to Model Traumatized Craniovascular Biodynamics

Sean S. Kohles, Ryan W. Mangan, Edward Stan, James McNames
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Technical Briefs
J. Med. Devices. March 2007, 1(1): 89–95.
https://doi.org/10.1115/1.2355689
Published Online: July 30, 2006
View Article titled, A First-Order Mechanical Device to Model Traumatized Craniovascular Biodynamics
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Topics: Biological tissues, Blood, Brain, Design, Flow (Dynamics), Physiology, Pressure, Traumatic brain injury, Wounds, Cerebrospinal fluid
Journal Articles

Linear Poroelastic Cancellous Bone Anisotropy: Trabecular Solid Elastic and Fluid Transport Properties

Sean S. Kohles, ASME Member, Julie B. Roberts
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2002, 124(5): 521–526.
https://doi.org/10.1115/1.1503374
Published Online: September 30, 2002
View Article titled, Linear Poroelastic Cancellous Bone Anisotropy: Trabecular Solid Elastic and Fluid Transport Properties
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Topics: Anisotropy, Biological tissues, Bone, Elasticity, Fluids, Porosity, Permeability, Elastic moduli, Biomechanics
Journal Articles

Thermographic Stress Analysis in Cortical Bone

Ray Vanderby, Jr., Sean S. Kohles
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 1991, 113(4): 418–422.
https://doi.org/10.1115/1.2895421
Published Online: November 1, 1991
View Article titled, Thermographic Stress Analysis in Cortical Bone
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Topics: Bone, Stress analysis (Engineering), Heat flux, Temperature, Stress, Biomechanics, Density, Strain gages, Thermoelasticity