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Proceedings Papers

Changes in Osteoblasts Under Time Averaged Microgravity Conditions

Clark T. Hung, Eric D. Johnston, Fred Allen, Mitchell Litt, Solomon R. Pollack, David F. Meaney
Proc. ASME. IMECE97, Advances in Heat and Mass Transfer in Biotechnology, 75-79, November 16–21, 1997
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1997-1314
https://doi.org/10.1115/IMECE1997-1314
View Paper titled, Changes in Osteoblasts Under Time Averaged Microgravity Conditions
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Topics: Osteoblasts, Biological tissues, Gravity (Force), Bone, DNA, Hydrostatic pressure, Reduced gravity environments, Stress
Proceedings Papers

Anterior Cruciate and Medial Collateral Ligament Fibroblasts Exhibit Different Ca 2+ Responses to Fluid Flow

Clark T. Hung, Fred D. Allen, Solomon R. Pollack, Eric T. Attia, Jo A. Hannafin, Peter A. Torzilli
Proc. ASME. IMECE96, Advances in Bioengineering, 95-96, November 17–22, 1996
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1996-1131
https://doi.org/10.1115/IMECE1996-1131
View Paper titled, Anterior Cruciate and Medial Collateral Ligament Fibroblasts Exhibit Different Ca 2+ Responses to Fluid Flow
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Topics: Fibroblasts, Fluid dynamics, Anterior cruciate ligament, Flow (Dynamics), Shear stress, Wounds
Proceedings Papers

Toward Defining the Role of Ca 2+ and MAP Kinases in Fluid-Induced Shear Regulation of Aggrecan in Chondrocytes

Clark T. Hung, Changbin B. Wang, Ross Henshaw, Wilmot B. Valhmu, Mary B. Goldring
Proc. ASME. IMECE98, Advances in Bioengineering, 59-60, November 15–20, 1998
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1998-0030
https://doi.org/10.1115/IMECE1998-0030
View Paper titled, Toward Defining the Role of Ca 2+ and MAP Kinases in Fluid-Induced Shear Regulation of Aggrecan in Chondrocytes
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Topics: Chondrocytes, Fluids, Shear (Mechanics), Proteins
Proceedings Papers

Direct Hydraulic Permeability Measurements of Agarose Hydrogels Used as Cell Scaffolds

Michael A. Soltz, Anna Stankiewicz, Gerard Ateshian, Robert L. Mauck, Clark T. Hung
Proc. ASME. IMECE99, Advances in Bioengineering, 229-230, November 14–19, 1999
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1999-0461
https://doi.org/10.1115/IMECE1999-0461
View Paper titled, Direct Hydraulic Permeability Measurements of Agarose Hydrogels Used as Cell Scaffolds
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Topics: Agar, Hydrogels, Permeability, Fluids, Chondrocytes, Cartilage, Fluid dynamics, Bearings, Compacting, Ions
Proceedings Papers

Is Articular Cartilage Orthotropic in Compression?

Michael A. Soltz, Robert L. Mauck, Clark T. Hung, Gerard A. Ateshian
Proc. ASME. IMECE99, Advances in Bioengineering, 209-210, November 14–19, 1999
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1999-0451
https://doi.org/10.1115/IMECE1999-0451
View Paper titled, Is Articular Cartilage Orthotropic in Compression?
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Topics: Cartilage, Compression, Tension, Anisotropy, Biological tissues, Strips
Proceedings Papers

Time-Varying Effect of Ascorbate on the Compressive Modulus and Gag Content of Chondrocyte-Seeded Agarose Cultures

Robert L. Mauck, Michael A. Soltz, Beth Gilbert, Gerard A. Ateshian, Clark T. Hung, Frank J. Raia, Wilmot B. Valhmu
Proc. ASME. IMECE99, Advances in Bioengineering, 105-106, November 14–19, 1999
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1999-0399
https://doi.org/10.1115/IMECE1999-0399
View Paper titled, Time-Varying Effect of Ascorbate on the Compressive Modulus and Gag Content of Chondrocyte-Seeded Agarose Cultures
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Topics: Agar, Chondrocytes, Disks, Cartilage, Mechanical properties, Assaying, Biological tissues
Proceedings Papers

Chondrocyte Translocation and Orientation to Applied DC Electric Fields

Robert L. Mauck, Pen-hsiu G. Chao, Beth Gilbert, Wilmot B. Valhmu, Clark T. Hung
Proc. ASME. IMECE99, Advances in Bioengineering, 117-118, November 14–19, 1999
Publisher: American Society of Mechanical Engineers
Paper No: IMECE1999-0405
https://doi.org/10.1115/IMECE1999-0405
View Paper titled, Chondrocyte Translocation and Orientation to Applied DC Electric Fields
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Topics: Chondrocytes, Electric fields, Cartilage, Bioengineering, Biological tissues, Bone, Cornea, Fibroblasts, Maintenance, Shapes
Proceedings Papers

Mechanical Loading Modulates Gene Expression in Chondrocyte-Seeded Agarose Hydrogels

Sansan S. Lo, Robert L. Mauck, Sara L. Seyhan, Glyn D. Palmer, Van C. Mow, Clark T. Hung
Proc. ASME. IMECE2001, Advances in Bioengineering, 291-292, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23145
https://doi.org/10.1115/IMECE2001/BED-23145
View Paper titled, Mechanical Loading Modulates Gene Expression in Chondrocyte-Seeded Agarose Hydrogels
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Topics: Agar, Chondrocytes, Hydrogels, Cartilage, Stress, Biological tissues, Bearings, Bioreactors, Compression, Dynamic testing (Materials)
Proceedings Papers

Temporal Development of Material Properties in Free Swelling Chondrocyte-Seeded Agarose Constructs

Terri-Ann N. Kelly, Christopher C.-B. Wang, Nadeen O. Chahine, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. IMECE2001, Advances in Bioengineering, 289-290, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23144
https://doi.org/10.1115/IMECE2001/BED-23144
View Paper titled, Temporal Development of Material Properties in Free Swelling Chondrocyte-Seeded Agarose Constructs
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Topics: Agar, Chondrocytes, Materials properties, Biological tissues, Biomechanics, Cartilage, Displacement, Hydrogels, Microscopy, Poisson ratio
Proceedings Papers

Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture

Robert L. Mauck, Michael A. Soltz, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. IMECE2001, Advances in Bioengineering, 295-296, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23147
https://doi.org/10.1115/IMECE2001/BED-23147
View Paper titled, Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture
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Topics: Chondrocytes, Hydrostatics, Cartilage, Hydrostatic pressure, Pressure, Stress, Bearings, Bone, Deformation, Hydrogels
Proceedings Papers

A Novel Device for Direct Permeation Measurements of Hydrogels and Soft Hydrated Tissues

Nelly A. Andarawis, Sara L. Seyhan, Robert L. Mauck, Michael A. Soltz, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. IMECE2001, Advances in Bioengineering, 299-300, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23149
https://doi.org/10.1115/IMECE2001/BED-23149
View Paper titled, A Novel Device for Direct Permeation Measurements of Hydrogels and Soft Hydrated Tissues
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Topics: Biological tissues, Hydrogels, Permeability, Cartilage, Deformation, Fluids, Agar, Bearings, Design, Lubrication
Proceedings Papers

The Strain-Softening of Bovine Articular Cartilage Under Infinitesimal Deformation in Unconfined Compression

Christopher C.-B. Wang, Nadeen O. Chahine, Terri-Ann N. Kelly, W. Michael Lai, Clark T. Hung, Gerard A. Ateshian
Proc. ASME. IMECE2001, Advances in Bioengineering, 123-124, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/BED-23061
https://doi.org/10.1115/IMECE2001/BED-23061
View Paper titled, The Strain-Softening of Bovine Articular Cartilage Under Infinitesimal Deformation in Unconfined Compression
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Topics: Cartilage, Compression, Deformation, Biological tissues, Osmosis, Buckling, Constitutive equations, Elasticity, Equilibrium (Physics), Fibers
Proceedings Papers

Dynamic Compression Stimulates the Development of Equilibrium Aggregate Modulus in Tissue Engineered Cartilage Constructs

Robert L. Mauck, Glyn D. Palmer, Christopher C.-B. Wang, Michael A. Soltz, Wilmot B. Valhmu, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. IMECE2000, Advances in Bioengineering, 67-68, November 5–10, 2000
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2000-2518
https://doi.org/10.1115/IMECE2000-2518
View Paper titled, Dynamic Compression Stimulates the Development of Equilibrium Aggregate Modulus in Tissue Engineered Cartilage Constructs
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Topics: Biological tissues, Cartilage, Compression, Equilibrium (Physics), Agar, Bearings, Functional materials, Physiology, Stress, Tissue engineering
Proceedings Papers

Cathodal Migration of Chondrocytes to Applied DC Electric Fields: Effects of Neomycin

Pen-hsiu G. Chao, Wendy Liu, Rani Roy, Robert L. Mauck, Clark T. Hung
Proc. ASME. IMECE2000, Advances in Bioengineering, 65-66, November 5–10, 2000
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2000-2517
https://doi.org/10.1115/IMECE2000-2517
View Paper titled, Cathodal Migration of Chondrocytes to Applied DC Electric Fields: Effects of Neomycin
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Topics: Chondrocytes, Electric fields, Temperature, Cartilage, Maintenance, Physiology
Journal Articles

Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena

Brandon K. Zimmerman, Robert J. Nims, Alex Chen, Clark T. Hung, Gerard A. Ateshian
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2021, 143(4): 041007.
Paper No: BIO-20-1368
https://doi.org/10.1115/1.4049158
Published Online: December 16, 2020
View Article titled, Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena
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Topics: Cartilage, Osmosis, Pressure, Biological tissues, Stress
Proceedings Papers

Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage

Liming Bian, Terri Ann N. Kelly, Eric G. Lima, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 269-270, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192368
https://doi.org/10.1115/SBC2008-192368
View Paper titled, Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage
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Topics: Biological tissues, Cartilage, Finite element analysis, Modeling, Bearings, Chondrocytes, Cracking (Materials), Fracture (Process), Hydrogels, Maintenance
Proceedings Papers

Genipin Protects Engineered Cartilage Against IL-1alpha Induced Degradation

Andrea R. Tan, Eric G. Lima, Kacey G. Marra, Clark T. Hung
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 621-622, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-193070
https://doi.org/10.1115/SBC2008-193070
View Paper titled, Genipin Protects Engineered Cartilage Against IL-1alpha Induced Degradation
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Topics: Cartilage, Biological tissues, Osteoarthritis, Surgery, Tissue engineering
Proceedings Papers

The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors

Christopher J. O’Conor, Kenneth W. Ng, Lindsay E. Kugler, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1023-1024, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176523
https://doi.org/10.1115/SBC2007-176523
View Paper titled, The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors
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Topics: Biological tissues, Cartilage, Tissue engineering, Agar, Biocompatibility, Chondrocytes, Mechanical properties
Proceedings Papers

Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage

Lindsay E. Kugler, Kenneth W. Ng, Christopher J. O’Conor, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1031-1032, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176558
https://doi.org/10.1115/SBC2007-176558
View Paper titled, Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage
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Topics: Biological tissues, Cartilage, Agar, Tissue engineering, Chondrocytes, Diffusion (Physics), Explosives, Maintenance, Physiology, Testing
Proceedings Papers

The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading

Elizabeth S. Oswald, Pen-hsiu Grace Chao, J. Chloe Bulinski, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 277-278, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176634
https://doi.org/10.1115/SBC2007-176634
View Paper titled, The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading
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Topics: Chondrocytes, Cartilage, Physiology, Signals