Magnetic drug targeting can be used for treating stenosis and thrombosis in partly occluded blood vessels. Herein, a numerical investigation of magnetic drug targeting using functionalized magnetic microspheres in partly occluded blood vessels is conducted. An Eulerian-Lagrangian technique is adopted to resolve the hemodynamic flow and the motion of the magnetic particles in the flow. An implantable cylindrical permanent magnet insert is used to create the requisite magnetic field. Targeted transport of the magnetic particles in a partly occluded vessel differs distinctly from the same in a regular unblocked vessel. Parametric investigation is conducted, and the influence of the flow Re, magnetic insert diameter, and its radial and axial position on the “targeting efficiency” is reported. Analysis shows that there exists an optimum regime of operating parameters for which deposition of the drug-carrying magnetic particles in a predesignated target zone on the partly occluded vessel wall can be maximized. The results provide useful design bases for an in vitro setup for the investigation of magnetic drug targeting in stenosed blood vessels.
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November 2010
Research Papers
Magnetic Drug Targeting in Partly Occluded Blood Vessels Using Magnetic Microspheres
Moloy K. Banerjee,
Moloy K. Banerjee
Department of Mechanical Engineering,
e-mail: moloy_kb@yahoo.com
Future Institute of Engineering and Management
, Kolkata 700150, India
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Amitava Datta,
Amitava Datta
Department of Power Engineering,
e-mail: amdatta_ju@yahoo.com
Jadavpur University
, Kolkata 700098, India
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Ranjan Ganguly
Ranjan Ganguly
Department of Power Engineering,
e-mail: ranjan@pe.jusl.ac.in
Jadavpur University
, Kolkata 700098, India
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Moloy K. Banerjee
Department of Mechanical Engineering,
Future Institute of Engineering and Management
, Kolkata 700150, Indiae-mail: moloy_kb@yahoo.com
Amitava Datta
Department of Power Engineering,
Jadavpur University
, Kolkata 700098, Indiae-mail: amdatta_ju@yahoo.com
Ranjan Ganguly
Department of Power Engineering,
Jadavpur University
, Kolkata 700098, Indiae-mail: ranjan@pe.jusl.ac.in
J. Nanotechnol. Eng. Med. Nov 2010, 1(4): 041005 (9 pages)
Published Online: October 21, 2010
Article history
Received:
July 28, 2010
Revised:
August 16, 2010
Online:
October 21, 2010
Published:
October 21, 2010
Citation
Banerjee, M. K., Datta, A., and Ganguly, R. (October 21, 2010). "Magnetic Drug Targeting in Partly Occluded Blood Vessels Using Magnetic Microspheres." ASME. J. Nanotechnol. Eng. Med. November 2010; 1(4): 041005. https://doi.org/10.1115/1.4002418
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