This research presents the development of neural recording electrodes with high sensitivity using nanotechnology and the evaluation of their electrochemical sensing properties. Neural electrodes with heterostructured nanowires have been fabricated on a flexible needle probe using a polyimide substrate. The outer, functional layer of the nanoelectrodes was made with a thin iridium oxide layer on vertically aligned Au nanowire cores providing low impedance and high charge storage capacity, which can enhance neural sensing and stimulating efficiency. Acute recording from the hippocampus of a rat brain has confirmed the neural sensing functionality of the heterostructured nanowire electrodes.
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1.
Dayan
, P.
, and Abbott
, L. F.
, 2005, Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems
, MIT
, Cambridge, MA
.2.
Nicolelis
, M. A. L.
, 2007, Methods for Neural Ensemble Recordings
, CRC
, Boca Raton, FL
.3.
Wessberg
, J.
, Stambaugh
, C. R.
, Kralik
, J. D.
, Beck
, P. D.
, Laubach
, M.
, Chapin
, J. K.
, Kim
, J.
, Biggs
, S. J.
, Srinivasan
, M. A.
, and Nicolelis
, M. A. L.
, 2000, “Real-Time Prediction of Hand Trajectory by Ensembles of Cortical Neurons In Primates
,” Nature (London)
0028-0836, 408
, pp. 361
–365
.4.
Horch
, K. W.
, and Dhillon
, G. S.
, 2004, Neuroprosthetics: Theory and Practice
, World Scientific
, NJ
.5.
Donoghue
, J. P.
, 2002, “Connecting Cortex to Machines: Recent Advances in Brain Interfaces
,” Nat. Neurosci.
1097-6256, 5
, pp. 1085
–1088
.6.
Lebedev
, M. A.
, and Nicolelis
, M. A. L.
, 2006, “Brain-Machine Interfaces: Past, Present and Future
,” Trends Neurosci.
0166-2236, 29
, pp. 536
–546
.7.
Jefferys
, J. G.
, 1995, “Nonsynaptic Modulation of Neuronal Activity in the Brain: Electric Currents and Extracellular Ions
,” Physiol. Rev.
0031-9333, 75
, pp. 689
–723
.8.
Chase
, D.
, 2006, Shattered Nerves: How Science Is Solving Modern Medicine’s Most Perplexing
, Johns Hopkins University Press
, Baltimore, MD
.9.
Schwartz
, A. B.
, 2006, “Neurobiology: Crossed Circuits
,” Nature (London)
0028-0836, 444
, pp. 47
–48
.10.
Buzsáki
, G.
, 2004, “Large-Scale Recording of Neuronal Ensembles
,” Nat. Neurosci.
1097-6256, 7
, pp. 446
–451
.11.
Williams
, J. C.
, Rennaker
, R. L.
, and Kipke
, D. R.
, 1999, “Long-Term Neural Recording Characteristics of Wire Microelectrode Arrays Implanted in Cerebral Cortex
,” Brain Res. Protoc
, 4
, pp. 303
–313
.12.
Cheung
, K. C.
, Renaud
, P.
, Tanila
, H.
, and Djupsund
, K.
, 2007, “Flexible Polyimide Microelectrode Array for In Vivo Recordings and Current Source Density Analysis
,” Biosens. Bioelectron.
0956-5663, 22
, pp. 1783
–1790
.13.
Wise
, K. D.
, 2005, “Chronic Microelectrode Recording Arrays
,” NIH quarterly report, Contract HHSN265200423631C.14.
Kim
, C.
, and Wise
, K. D.
, 1994, “A 64-Site Multiplexed Low Profile Neural Probe With On-Chip CMOS Circuitry
,” Proceedings of the IEEE VLSI Circuits
, pp. 97
–98
.15.
Wise
, K. D.
, Angell
, J. B.
, and Starr
, A.
, 1970, “An Integrated-Circuit Approach to Extracellular Microelectrodes
,” IEEE Trans. Biomed. Eng.
0018-9294, BME-17
, pp. 238
–247
.16.
Campbell
, P. K.
, Jones
, K. E.
, Huber
, R. J.
, Horch
, K. W.
, and Normann
, R. A.
, 1991, “A Silicon-Based, Three-Dimensional Neural Interface: Manufacturing Processes for an Intercortical Electrode Array
,” IEEE Trans. Biomed. Eng.
0018-9294, 38
, pp. 758
–768
.17.
Yoon
, H.
, Deshpande
, D. C.
, Varadan
, V. K.
, Kim
, T.
, Jeong
, E.
, and Harbaugh
, R. E.
, 2010, “Development of Titanium Needle Probes for Neural Recording
,” J. Nanotech. Eng. Medicine
, 1
, p. 011004
.18.
Rousche
, P. J.
, Pellinen
, D. S.
, Pivin
, D. P.
, Williams
, J. C.
, and Kipke
, D. R.
, 2001, “Flexible Polyimide-Based Intracortical Electrode Arrays With Bioactive Capability
,” IEEE Trans. Biomed. Eng.
0018-9294, 48
, pp. 361
–371
.19.
Zhong
, Y.
, and Bellamkonda
, R. V.
, 2007, “Dexamethasone Coated Neural Probes Elicit Attenuated Inflammatory Response and Neuronal Loss Compared to Uncoated Neural Probes
,” Brain Res.
0006-8993, 1148
, pp. 15
–27
.20.
Kim
, D.
, and Martin
, D. C.
, 2006, “Sustained Release of Dexamethasone From Hydrophilic Matrices Using PLGA Nanoparticles for Neural Drug Delivery
,” Biomaterials
0142-9612, 27
, pp. 3031
–3037
.21.
Shain
, W.
, Spataro
, L.
, Dilgen
, J.
, Haverstick
, K.
, and Retterer
, S.
, 2003, “Controlling Cellular Reactive Responses Around Neural Prosthetic Devices Using Peripheral and Local Intervention Strategies
,” IEEE Trans. Neural Syst. Rehabil. Eng.
1534-4320, 11
, pp. 186
–188
.22.
Johnson
, M. D.
, Otto
, K. J.
, and Kipke
, D. R.
, 2005, “Repeated Voltage Biasing Improves Unit Recordings by Reducing Resistive Tissue Impedances
,” IEEE Trans. Neural Syst. Rehabil. Eng.
1534-4320, 13
, pp. 160
–165
.23.
Pancrazio
, J. J.
, 2008, “Neural Interfaces at the Nanoscale
,” Nanomedicine
1743-5889, 3
, pp. 823
–830
.24.
Yoon
, H.
, Deshpande
, D. C.
, Ramachandran
, V.
, and Varadan
, V. K.
, 2008, “Aligned Nanowire Growth Using Lithography-Assisted Bonding of Polycarbonate Template for Neural Probe Electrodes
,” Nanotechnology
0957-4484, 19
, p. 025304
.25.
Cheung
, K. C.
, Choi
, Y.
, Kubow
, T.
, and Lee
, L. P.
, 2002, “Nanostructured Electrodes for Improved Neural Recording,” Symposium Proceedings of the Materials Research Society (BioMEMS and Biotechnology), 729
, pp. 191
–196
.26.
Wang
, K.
, Fishman
, H. A.
, Dai
, H.
, and Harris
, J. S.
, 2006, “Neural Stimulation With a Carbon Nanotube Microelectrode Array
,” Nano Lett.
1530-6984, 6
, pp. 2043
–2048
.27.
Yoon
, H.
, Hankins
, P.
, Varadan
, V. K.
, and Harbaugh
, R. E.
, 2008, “Dual Electrode Ensembles With Core and Shell Nanoelectrodes for Dopamine Sensing Applications
,” Electroanalysis
1040-0397, 20
, pp. 1147
–1150
.28.
Cogan
, S. F.
, 2008, “Neural Stimulation and Recording Electrodes
,” Annu. Rev. Biomed. Eng.
1523-9829, 10
, pp. 275
–309
.29.
Negi
, S.
, Bhandari
, R.
, Rieth
, L.
, and Solzbacher
, F.
, 2010, “In Vitro Comparison of Sputtered Iridium Oxide and Platinum-Coated Neural Implantable Microelectrode Arrays
,” Biomed. Mater.
, 5
, p. 015007
.30.
Yamanaka
, K.
, 1989, “Anodically Electrodeposited Iridium Oxide Films (AEIROF) From Alkaline Solutions for Electrochromic Display Devices
,” Jpn. J. Appl. Phys., Part 1
0021-4922, 28
, pp. 632
–637
.31.
Meyer
, R. D.
, Cogan
, S. F.
, Nguyen
, T. H.
, and Rauh
, R. D.
, 2001, “Electrodeposited Iridium Oxide for Neural Stimulation and Recording Electrodes
,” IEEE Trans. Neural Syst. Rehabil. Eng.
1534-4320, 9
, pp. 2
–11
.32.
Grahame
, D. C.
, 1947, “The Electrical Double Layer and the Theory of Electrocapillarity
,” Chem. Rev.
0009-2665, 41
, pp. 441
–501
.33.
Bard
, A. J.
, and Faulkner
, L. R.
, 2001, Electrochemical Methods: Fundamentals and Applications
, 2nd ed., Wiley
, New York
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