The generalized integral transform technique (GITT) is reviewed as a computational–analytical methodology in linear and nonlinear convection–diffusion problems, based on eigenfunction expansions extracted from characteristic differential operators, coefficients, and boundary conditions present in the original partial differential problem formulation. Here, the emphasis is on the employment of nonclassical eigenvalue problems as the expansion basis, which do not fall into the more usual framework of Sturm–Liouville problems. The goal is to enable or improve the eigenfunction expansions convergence, by incorporating more information from the original operators into the chosen eigenvalue problem, while requiring the handling of such a more involved expansion base. In this concern, the proposed differential eigenvalue problem can itself be handled by the GITT, leading to an algebraic eigensystem analysis. Different classes of nonclassical eigenvalue problems are then reviewed and associated with typical applications in heat and mass transfer. Representative test cases are then chosen to illustrate the extended methodology and demonstrate the convergence rates attainable by this enhanced hybrid solution path.