...Reed Chen; Julian A. Rey; Ibrahim S. Tuna; David D. Tran; Malisa Sarntinoranont Adeno-associated virus (AAV) is a clinically useful gene delivery vehicle for treating neurological diseases. To deliver AAV to focal targets, direct infusion into brain tissue by convection-enhanced delivery (CED...

..., a reliable method for the quantification of the anisotropic mechanical properties of human white matter is currently lacking, despite the potential to illuminate the pathophysiology behind neurological disorders and traumatic brain injury. In this study, we examine the use of multiple excitations in MRE...

... studies have investigated the biochemical and genetic aspects of ASD, whether and how mechanical characteristics of the autistic brain can modulate neuronal connectivity and cognition in ASD are unknown. Previously, it has been shown that ASD brains are characterized by abnormal white matter...

...Yun-Seok Kang; Kevin Moorhouse; John H. Bolte, IV The ability to measure six degrees of freedom (6 DOF) head kinematics in motor vehicle crash conditions is important for assessing head-neck loads as well as brain injuries. A method for obtaining accurate 6 DOF head kinematics in short duration...

...Benjamin S. Elkin; Ashok Ilankova; Barclay Morrison, III Stress relaxation tests using a custom designed microindentation device were performed on ten anatomic regions of fresh porcine brain (postmortem time <3 h). Using linear viscoelastic theory, a Prony series representation was used...

... and the assigned material parameters at a different pressure. The nodal displacements are found in excellent agreement. 09 12 2010 10 03 2011 28 03 2011 03 05 2011 03 05 2011 biological tissues biomechanics brain elasticity finite element analysis inverse problems...

... of deformation. We demonstrate the use of this methodology by determining the minimal rheological arrangement, constitutive relationships, and model parameters for the structural response of various soft tissues, including ex vivo perfused porcine liver in indentation, ex vivo porcine brain cortical tissue...

...Guanglei Li; Bingmei M. Fu The endothelial surface glycocalyx layer (SGL) and the basement membrane (BM) are two important components of the blood-brain barrier (BBB). They provide large resistance to solute transport across the BBB in addition to the tight junctions in the cleft between adjacent...

...Andrew K. Knutsen; Yulin V. Chang; Cindy M. Grimm; Ly Phan; Larry A. Taber; Philip V. Bayly Folding of the cerebral cortex is a critical phase of brain development in higher mammals but the biomechanics of folding remain incompletely understood. During folding, the growth of the cortical surface...

... of these hemodynamic factors in vivo is challenging but computational fluid dynamics (CFD) modeling can be used to estimate the hemodynamics in the cerebral vascular system ( 8 9 10 11 12 ). aneurysms animal models parent vasculature hemodynamics CFD wall shear stress blood vessels brain...

...Gang Xu; Andrew K. Knutsen; Krikor Dikranian; Christopher D. Kroenke; Philip V. Bayly; Larry A. Taber During human brain development, the cerebral cortex undergoes substantial folding, leading to its characteristic highly convoluted form. Folding is necessary to accommodate the expansion...

...O. Ivanchenko; N. Sindhwani; A. Linninger Convection enhanced delivery is an attractive option for the treatment of several neurodegenerative diseases such as Parkinson, Alzheimer, and brain tumors. However, the occurrence of a backflow is a major problem impeding the widespread use...

...Benjamin S. Elkin; Ashok Ilankovan; Barclay Morrison, III Age-dependent outcomes following traumatic brain injury motivate the study of brain injury biomechanics in experimental animal models at different stages of development. Finite element models of the rat brain are used to better understand...

...Gang Xu; Philip S. Kemp; Joyce A. Hwu; Adam M. Beagley; Philip V. Bayly; Larry A. Taber Mechanical forces play an important role during brain development. In the early embryo, the anterior end of the neural tube enlarges and differentiates into the major brain subdivisions, including three...

... than that of interface friction. Taken together, these findings demonstrate the advantages of flash freezing in biomechanical studies of spine cord tissue. 02 12 2008 11 05 2009 01 09 2009 26 10 2009 biological tissues biomechanics biothermics brain finite element...

... stiffness and strength ( 7 8 ). biomechanics bone brain finite element analysis 03 09 2008 20 05 2009 16 10 2009 2009 American Society of Mechanical Engineers ...

... blood vessels brain diseases failure analysis fatigue finite element analysis haemodynamics proteins cerebral arteries multi-mechanism aneurysms structural damage model Intracranial aneurysms (ICAs) are abnormal dilatations of the cerebral arterial walls...

...). The cylindrical structure (top right figure) constitutes the reference configuration of the posed problem. 24 11 2008 08 07 2009 04 09 2009 anisotropic media biomechanics blood vessels brain diseases elasticity proteins shear strength aneurysm artery cerebral collagen...

.... , Tateshima , S. , Tanishita , K. , Vinuela , F. , and Sinha , S. , 2007 , “ Fluid-Induced WSS in Anthropomorphic Brain Aneurysm Models: MR Phase-Contrast Study at 3T ,” J. Magn. Reson Imaging 1053-1807 , 25 , pp. 1120 – 1130 . 10.1002/jmri.20928 Hoi , Y. , Meng , H...

... biomechanics blood vessels brain diseases haemodynamics neurophysiology non-Newtonian flow pulsatile flow non-Newtonian fluid intracranial aneurysm shear stress ellipticity computational fluid dynamics rupture Aneurysms, local dilations of arterial walls, may continue to expand until...