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Journal Articles

Computational Pulsatile Flow and Efficiency Analysis of Biocompatible Microfluidic Artificial Lungs for Different Fiber Configurations

Ahmet Yusuf Asiltürk, Kunt Atalık
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2024, 146(8): 081002.
Paper No: BIO-23-1143
https://doi.org/10.1115/1.4064793
Published Online: March 21, 2024
View Article titled, Computational Pulsatile Flow and Efficiency Analysis of Biocompatible Microfluidic Artificial Lungs for Different Fiber Configurations
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Topics: Artificial lungs, Biocompatibility, Blood, Fibers, Flow (Dynamics), Membranes, Microfluidics, Oxygen, Pressure drop, Pulsatile flow
Journal Articles

Performance Optimization of a Microfluidic Virus Detection Cartridge: A Numerical and Experimental Study

Enes Burak Şenel, Bilal Kizilelma, Enes Tamdoğan, Mustafa Yorulmaz
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2023, 145(10): 101010.
Paper No: BIO-23-1058
https://doi.org/10.1115/1.4062850
Published Online: July 14, 2023
View Article titled, Performance Optimization of a Microfluidic Virus Detection Cartridge: A Numerical and Experimental Study
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Topics: Flow (Dynamics), Geometry, Microchannels, Microfluidics, Optimization, Biosensors, Optical microscopy
Journal Articles

Confined Cell Migration and Asymmetric Hydraulic Environments to Evaluate the Metastatic Potential of Cancer Cells

Yago Juste-Lanas, Pedro Enrique Guerrero, Daniel Camacho-Gómez, Silvia Hervás-Raluy, Jose M. García-Aznar, María J. Gomez-Benito
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2022, 144(7): 074502.
Paper No: BIO-21-1259
https://doi.org/10.1115/1.4053143
Published Online: February 15, 2022
View Article titled, Confined Cell Migration and Asymmetric Hydraulic Environments to Evaluate the Metastatic Potential of Cancer Cells
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Topics: Cancer, Microfluidics, Tumors
Includes: Supplementary data
Journal Articles

A Microfluidic System to Measure Neonatal Lung Compliance Over Late Stage Development as a Functional Measure of Lung Tissue Mechanics

Laurel E. Schappell, Daniel J. Minahan, Jason P. Gleghorn
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2020, 142(10): 100803.
Paper No: BIO-19-1556
https://doi.org/10.1115/1.4047133
Published Online: August 31, 2020
View Article titled, A Microfluidic System to Measure Neonatal Lung Compliance Over Late Stage Development as a Functional Measure of Lung Tissue Mechanics
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Topics: Lung, Biological tissues, Microfluidics, Pressure, Calibration
Journal Articles

Internal Viscosity-Dependent Margination of Red Blood Cells in Microfluidic Channels

Faisal Ahmed, Marmar Mehrabadi, Zixiang Liu, Gilda A. Barabino, Cyrus K. Aidun
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2018, 140(6): 061013.
Paper No: BIO-17-1250
https://doi.org/10.1115/1.4039897
Published Online: April 30, 2018
View Article titled, Internal Viscosity-Dependent Margination of Red Blood Cells in Microfluidic Channels
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Topics: Erythrocytes, Flow (Dynamics), Microfluidics, Shear rate, Simulation, Viscosity, Deformation, Equilibrium (Physics)
Includes: Supplementary data
Journal Articles

Mathematical Model for Tissue-Level Hypoxic Response in Microfluidic Environment

Adnan Morshed, Prashanta Dutta
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2018, 140(1): 011009.
Paper No: BIO-17-1090
https://doi.org/10.1115/1.4037915
Published Online: November 9, 2017
View Article titled, Mathematical Model for Tissue-Level Hypoxic Response in Microfluidic Environment
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Topics: Biological tissues, Microfluidics, Oxygen, Cancer
Includes: Supplementary data
Journal Articles

2016 Summer Biomechanics, Bioengineering, and Biotransport Conference Student Paper Competition

Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Editorial
J Biomech Eng. February 2017, 139(2): 020207.
Paper No: BIO-16-1523
https://doi.org/10.1115/1.4035643
Published Online: January 19, 2017
View Article titled, 2016 Summer Biomechanics, Bioengineering, and Biotransport Conference Student Paper Competition
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Topics: Bioengineering, Biological tissues, Biomaterials, Biomechanics, Biotransport, Diseases, Fluids, Heat transfer, Human dynamics, Imaging
Journal Articles

In Vitro Evaluation of the Link Between Cell Activation State and Its Rheological Impact on the Microscale Flow of Neutrophil Suspensions

Michael L. Akenhead, Nolan M. Horrall, Dylan Rowe, Palaniappan Sethu, Hainsworth Y. Shin
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2015, 137(9): 091003.
Paper No: BIO-14-1569
https://doi.org/10.1115/1.4030824
Published Online: September 1, 2015
View Article titled, In Vitro Evaluation of the Link Between Cell Activation State and Its Rheological Impact on the Microscale Flow of Neutrophil Suspensions
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Topics: Erythrocytes, Flow (Dynamics), Rheology, Microscale devices, Microfluidics, Viscosity, Leukocytes
Journal Articles

Dynamics of Interstitial Fluid Pressure in Extracellular Matrix Hydrogels in Microfluidic Devices

Joe Tien, Le Li, Ozgur Ozsun, Kamil L. Ekinci
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2015, 137(9): 091009.
Paper No: BIO-15-1152
https://doi.org/10.1115/1.4031020
Published Online: July 22, 2015
View Article titled, Dynamics of Interstitial Fluid Pressure in Extracellular Matrix Hydrogels in Microfluidic Devices
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Topics: Dynamics (Mechanics), Fluid pressure, Microfluidics, Plasma desorption mass spectrometry, Pressure, Diffusion (Physics), Permeability, Scaling laws (Mathematical physics)
Includes: Supplementary data
Journal Articles

Device-Based In Vitro Techniques for Mechanical Stimulation of Vascular Cells: A Review

Caleb A. Davis, Steve Zambrano, Pratima Anumolu, Alicia C. B. Allen, Leonardo Sonoqui, Michael R. Moreno
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. April 2015, 137(4): 040801.
Paper No: BIO-13-1508
https://doi.org/10.1115/1.4029016
Published Online: April 1, 2015
View Article titled, Device-Based In Vitro Techniques for Mechanical Stimulation of Vascular Cells: A Review
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Topics: Flow (Dynamics), Pressure, Shear stress, Vessels, Microfluidics, Fluids
Journal Articles

Design of a Microfluidic System for Red Blood Cell Aggregation Investigation

R. Mehri, C. Mavriplis, M. Fenech
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. June 2014, 136(6): 064501.
Paper No: BIO-13-1317
https://doi.org/10.1115/1.4027351
Published Online: April 18, 2014
View Article titled, Design of a Microfluidic System for Red Blood Cell Aggregation Investigation
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Topics: Blood, Design, Erythrocytes, Flow (Dynamics), Fluids, Microchannels, Microfluidics, Plasmas (Ionized gases), Shear rate, Computer simulation
Journal Articles

Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y-Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion

Yong-Jiang Li, Yizeng Li, Tun Cao, Kai-Rong Qin
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2013, 135(12): 121011.
Paper No: BIO-13-1063
https://doi.org/10.1115/1.4025774
Published Online: November 12, 2013
View Article titled, Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y-Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion
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Topics: Diffusion (Physics), Flow (Dynamics), Signals, Transfer functions, Microfluidics
Journal Articles

Investigation of Hydrodynamic Focusing in a Microfluidic Coulter Counter Device

Muheng Zhang, Yongsheng Lian, Cindy Harnett, Ellen Brehob
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2012, 134(8): 081001.
https://doi.org/10.1115/1.4007091
Published Online: August 6, 2012
View Article titled, Investigation of Hydrodynamic Focusing in a Microfluidic Coulter Counter Device
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Topics: Flow (Dynamics), Microfluidics, Microchannels, Diffusion (Physics), Fluids
Journal Articles

A Porous Elastic Model for Bacterial Biofilms: Application to the Simulation of Deformation of Bacterial Biofilms Under Microfluidic Jet Impingement

Leo Y. Zheng, Dylan S. Farnam, Dorel Homentcovschi, Bahgat G. Sammakia
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. May 2012, 134(5): 051003.
https://doi.org/10.1115/1.4006683
Published Online: May 25, 2012
View Article titled, A Porous Elastic Model for Bacterial Biofilms: Application to the Simulation of Deformation of Bacterial Biofilms Under Microfluidic Jet Impingement
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Topics: Computer simulation, Deformation, Flow (Dynamics), Fluid structure interaction, Fluids, Microfluidics, Nozzles, Porous materials, Reynolds number, Shear stress
Journal Articles

Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells

Sean S. Kohles, Yu Liang, Asit K. Saha
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. January 2011, 133(1): 011004.
https://doi.org/10.1115/1.4002939
Published Online: December 22, 2010
View Article titled, Volumetric Stress-Strain Analysis of Optohydrodynamically Suspended Biological Cells
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Topics: Biological cells, Biomechanics, Stress, Microfluidics, Flow (Dynamics)
Journal Articles

A Microfluidic Device to Establish Concentration Gradients Using Reagent Density Differences

Qingjun Kong, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. December 2010, 132(12): 121012.
https://doi.org/10.1115/1.4002797
Published Online: November 16, 2010
View Article titled, A Microfluidic Device to Establish Concentration Gradients Using Reagent Density Differences
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Topics: Bridges (Structures), Diffusion (Physics), Flow (Dynamics), Manufacturing, Microchannels, Microfluidics, Plasma desorption mass spectrometry, Density, Design, Microfabrication
Journal Articles

Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations

Sean S. Kohles, Nathalie Nève, Jeremiah D. Zimmerman, Derek C. Tretheway
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. December 2009, 131(12): 121006.
https://doi.org/10.1115/1.4000121
Published Online: November 10, 2009
View Article titled, Mechanical Stress Analysis of Microfluidic Environments Designed for Isolated Biological Cell Investigations
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Topics: Flow (Dynamics), Fluids, Stress, Gravity (Force), Microfluidics, Shear (Mechanics), Microchannel flow
Journal Articles

A Microfluidic Manipulator for Enrichment and Alignment of Moving Cells and Particles

Hsiu-hung Chen, Bingbing Sun, Kenny K. Tran, Hong Shen, Dayong Gao
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074505.
https://doi.org/10.1115/1.3127258
Published Online: June 4, 2009
View Article titled, A Microfluidic Manipulator for Enrichment and Alignment of Moving Cells and Particles
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Topics: Microfluidics, Particulate matter, Flow (Dynamics)
Journal Articles

Numerical Characterization of Diffusion-Based Extraction in Cell-Laden Flow Through a Microfluidic Channel

K. K. Fleming, E. K. Longmire, A. Hubel
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 703–711.
https://doi.org/10.1115/1.2768373
Published Online: December 11, 2006
View Article titled, Numerical Characterization of Diffusion-Based Extraction in Cell-Laden Flow Through a Microfluidic Channel
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Topics: Diffusion (Physics), Flow (Dynamics), Permeability, Microfluidics, Design, Fluids, Cell membranes
Journal Articles

Neuro-Genetic Optimization of Temperature Control for a Continuous Flow Polymerase Chain Reaction Microdevice

Hing Wah Lee, Parthiban Arunasalam, William P. Laratta, Kankanhalli N. Seetharamu, Ishak A. Azid
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. August 2007, 129(4): 540–547.
https://doi.org/10.1115/1.2746376
Published Online: December 11, 2006
View Article titled, Neuro-Genetic Optimization of Temperature Control for a Continuous Flow Polymerase Chain Reaction Microdevice
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Topics: Artificial neural networks, Chain, Finite element analysis, Flow (Dynamics), Fluids, Genetic algorithms, Optimization, Simulation, Temperature, Temperature control