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Journal Articles

A Bioreactor for Controlled Electrical and Mechanical Stimulation of Developing Scaffold-Free Constructs

Sarah K. Van Houten, Michael T. K. Bramson, David T. Corr
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. September 2022, 144(9): 094501.
Paper No: BIO-21-1379
https://doi.org/10.1115/1.4054021
Published Online: March 30, 2022
View Article titled, A Bioreactor for Controlled Electrical and Mechanical Stimulation of Developing Scaffold-Free Constructs
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Topics: Biological tissues, Bioreactors, Calibration, Fibers, Manufacturing, Cycles, Tissue engineering, Plates (structures)
Journal Articles

A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants

Krishna Pedaprolu, Spencer E. Szczesny
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2022, 144(8): 084505.
Paper No: BIO-21-1377
https://doi.org/10.1115/1.4053795
Published Online: March 9, 2022
View Article titled, A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants
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Topics: Biological tissues, Bioreactors, Stress, Tendons, Fatigue
Includes: Supplementary data
Journal Articles

Computer-Controlled Biaxial Bioreactor for Investigating Cell-Mediated Homeostasis in Tissue Equivalents

J. F. Eichinger, D. Paukner, J. M. Szafron, R. C. Aydin, J. D. Humphrey, C. J. Cyron
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2020, 142(7): 071011.
Paper No: BIO-19-1337
https://doi.org/10.1115/1.4046201
Published Online: April 8, 2020
View Article titled, Computer-Controlled Biaxial Bioreactor for Investigating Cell-Mediated Homeostasis in Tissue Equivalents
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Topics: Biological tissues, Bioreactors, Computers, Density, Stress, Strips, Relaxation (Physics), Tension
Includes: Supplementary data
Journal Articles

Cellular Response to Cyclic Compression of Tissue Engineered Intervertebral Disk Constructs Composed of Electrospun Polycaprolactone

Andrea Fotticchia, Emrah Demirci, Cristina Lenardi, Yang Liu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2018, 140(6): 061002.
Paper No: BIO-17-1372
https://doi.org/10.1115/1.4039307
Published Online: March 16, 2018
View Article titled, Cellular Response to Cyclic Compression of Tissue Engineered Intervertebral Disk Constructs Composed of Electrospun Polycaprolactone
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Topics: Agar, Anisotropy, Biological tissues, Bioreactors, Bone, Compression, Compressive stress, Disks, Displacement, Electrospinning
Journal Articles

Functional Validation of a Complex Loading Whole Spinal Segment Bioreactor Design

Amanda M. Beatty, Anton E. Bowden, Laura C. Bridgewater
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. June 2016, 138(6): 064501.
Paper No: BIO-15-1538
https://doi.org/10.1115/1.4033546
Published Online: May 11, 2016
View Article titled, Functional Validation of a Complex Loading Whole Spinal Segment Bioreactor Design
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Topics: Bioreactors, Design, Testing, Disks, Stress
Journal Articles

A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions

Sharan Ramaswamy, Steven M. Boronyak, Trung Le, Andrew Holmes, Fotis Sotiropoulos, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2014, 136(12): 121009.
Paper No: BIO-13-1301
https://doi.org/10.1115/1.4028815
Published Online: December 1, 2014
View Article titled, A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions
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Topics: Biological tissues, Bioreactors, Flow (Dynamics), Fluids, Shear stress, Valves, Physiology, Design
Journal Articles

Investigation of the In Vitro Culture Process for Skeletal-Tissue-Engineered Constructs Using Computational Fluid Dynamics and Experimental Methods

Md. Shakhawath Hossain, X. B. Chen, D. J. Bergstrom
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2012, 134(12): 121003.
https://doi.org/10.1115/1.4007952
Published Online: November 27, 2012
View Article titled, Investigation of the In Vitro Culture Process for Skeletal-Tissue-Engineered Constructs Using Computational Fluid Dynamics and Experimental Methods
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Topics: Biological tissues, Bioreactors, Computational fluid dynamics, Flow (Dynamics), Fluid dynamics, Shear stress, Thermoelectric coolers, Mass transfer, Fluids, Modeling
Journal Articles

Effect of Pulse Frequency on the Osteogenic Differentiation of Mesenchymal Stem Cells in a Pulsatile Perfusion Bioreactor

Katherine D. Kavlock, Aaron S. Goldstein
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. September 2011, 133(9): 091005.
https://doi.org/10.1115/1.4004919
Published Online: October 11, 2011
View Article titled, Effect of Pulse Frequency on the Osteogenic Differentiation of Mesenchymal Stem Cells in a Pulsatile Perfusion Bioreactor
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Topics: Bioreactors, Bone, Flow (Dynamics), Proteins, Pulsatile flow, Stem cells, PLGA
Journal Articles

Novel Technique for Online Characterization of Cartilaginous Tissue Properties

Tai-Yi Yuan, Chun-Yuh Huang, Wei Yong Gu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. September 2011, 133(9): 094504.
https://doi.org/10.1115/1.4004920
Published Online: October 11, 2011
View Article titled, Novel Technique for Online Characterization of Cartilaginous Tissue Properties
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Topics: Annulus, Biological tissues, Bioreactors, Cartilage, Tissue engineering, Water, Density, Design
Journal Articles

Mass Transport in a Microchannel Bioreactor With a Porous Wall

Xiao Bing Chen, Yi Sui, Heow Pueh Lee, Hui Xing Bai, Peng Yu, S. H. Winoto, Hong Tong Low
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. June 2010, 132(6): 061001.
https://doi.org/10.1115/1.4001044
Published Online: April 16, 2010
View Article titled, Mass Transport in a Microchannel Bioreactor With a Porous Wall
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Topics: Bioreactors, Convection, Dams, Diffusion (Physics), Flow (Dynamics), Fluids, Microchannels, Porous materials, Mass transfer
Journal Articles

The Influence of Bioreactor Geometry and the Mechanical Environment on Engineered Tissues

J. M. Osborne, R. D. O’Dea, J. P. Whiteley, H. M. Byrne, S. L. Waters
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051006.
https://doi.org/10.1115/1.4001160
Published Online: March 25, 2010
View Article titled, The Influence of Bioreactor Geometry and the Mechanical Environment on Engineered Tissues
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Topics: Biological tissues, Bioreactors, Pressure, Stress, Wavelength, Density, Geometry, Shear stress, Shear (Mechanics)
Journal Articles

Design and Development of a Novel Biostretch Apparatus for Tissue Engineering

Qiming Pang, Jean W. Zu, Geoffrey M. Siu, Ren-Ke Li
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. January 2010, 132(1): 014503.
https://doi.org/10.1115/1.3005154
Published Online: December 8, 2009
View Article titled, Design and Development of a Novel Biostretch Apparatus for Tissue Engineering
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Topics: Biological tissues, Design, Tissue engineering, Bioreactors, Silicon, Control systems
Journal Articles

Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells Exposed to Physiological Coronary Wall Shear Stresses

Lucy M. O'Keeffe, Gordon Muir, Anna V. Piterina, Tim McGloughlin
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2009, 131(8): 081003.
https://doi.org/10.1115/1.3148191
Published Online: June 19, 2009
View Article titled, Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells Exposed to Physiological Coronary Wall Shear Stresses
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Topics: Adhesion, Atherosclerosis, Bifurcation, Endothelial cells, Flow (Dynamics), Hemodynamics, Physiology, Proteins, Shear (Mechanics), Shear stress
Journal Articles

Multi-Axial Mechanical Stimulation of HUVECs Demonstrates That Combined Loading is not Equivalent to the Superposition of Individual Wall Shear Stress and Tensile Hoop Stress Components

Liam T. Breen, Peter E. McHugh, Bruce P. Murphy
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. August 2009, 131(8): 081001.
https://doi.org/10.1115/1.3127248
Published Online: June 17, 2009
View Article titled, Multi-Axial Mechanical Stimulation of HUVECs Demonstrates That Combined Loading is not Equivalent to the Superposition of Individual Wall Shear Stress and Tensile Hoop Stress Components
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Topics: Bioreactors, Flow (Dynamics), Shear stress, Testing
Journal Articles

Differential Translocation of Nuclear Factor-KappaB in a Cardiac Muscle Cell Line Under Gravitational Changes

Ohwon Kwon, Michael Tranter, W. Keith Jones, John M. Sankovic, Rupak K. Banerjee
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. June 2009, 131(6): 064503.
https://doi.org/10.1115/1.3128718
Published Online: May 8, 2009
View Article titled, Differential Translocation of Nuclear Factor-KappaB in a Cardiac Muscle Cell Line Under Gravitational Changes
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Topics: Bioreactors, Enzymes, Muscle, Myocardium, Physiology, Oxidation, Proteins, Stress, Gravity (Force), Performance
Journal Articles

Simulating the Growth of Articular Cartilage Explants in a Permeation Bioreactor to Aid in Experimental Protocol Design

Timothy P. Ficklin, Andrew Davol, Stephen M. Klisch
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2009, 131(4): 041008.
https://doi.org/10.1115/1.3049856
Published Online: February 3, 2009
View Article titled, Simulating the Growth of Articular Cartilage Explants in a Permeation Bioreactor to Aid in Experimental Protocol Design
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Topics: Biological tissues, Biomechanics, Bioreactors, Boundary-value problems, Cartilage, Finite element analysis, Shear (Mechanics), Steady state, Stress, Compression
Journal Articles

Bioreactor for Biaxial Mechanical Stimulation to Tissue Engineered Constructs

Karin A. Wartella, Jennifer S. Wayne
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2009, 131(4): 044501.
https://doi.org/10.1115/1.3049859
Published Online: January 20, 2009
View Article titled, Bioreactor for Biaxial Mechanical Stimulation to Tissue Engineered Constructs
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Topics: Biological tissues, Bioreactors, Compression, Tension, Design, Tissue engineering
Journal Articles

Development and Validation of a System for the Growth of Cells and Tissues Under Intermittent Hydrostatic Pressure

Troy J. Eggum, Christopher J. Hunter
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. December 2008, 130(6): 064501.
https://doi.org/10.1115/1.2979864
Published Online: October 10, 2008
View Article titled, Development and Validation of a System for the Growth of Cells and Tissues Under Intermittent Hydrostatic Pressure
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Topics: Biological tissues, Bioreactors, Design, Glucose, Hydrostatic pressure, Oxygen, Pressure, Stem cells, Pressure testing, Intervertebral discs
Journal Articles

Numerical Simulation of Mass Transport in a Microchannel Bioreactor With Cell Micropatterning

Yan Zeng, Thong-See Lee, Peng Yu, Hong-Tong Low
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. June 2008, 130(3): 031018.
https://doi.org/10.1115/1.2913231
Published Online: May 6, 2008
View Article titled, Numerical Simulation of Mass Transport in a Microchannel Bioreactor With Cell Micropatterning
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Topics: Absorption, Bioreactors, Mass transfer, Microchannels
Journal Articles

Design of an Ex Vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue

Philippe Sucosky, Muralidhar Padala, Adnan Elhammali, Kartik Balachandran, Hanjoong Jo, Ajit P. Yoganathan
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Design Innovations
J Biomech Eng. June 2008, 130(3): 035001.
https://doi.org/10.1115/1.2907753
Published Online: April 22, 2008
View Article titled, Design of an Ex Vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue
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Topics: Biological tissues, Bioreactors, Cardiovascular system, Computational fluid dynamics, Design, Flow (Dynamics), Shear stress, Valves, Geometry, Laser Doppler anemometry