Knowing the forces in the human body is of great clinical interest and musculoskeletal (MS) models are the most commonly used tool to estimate them in vivo. Unfortunately, the process of computing muscle, joint contact, and ligament forces simultaneously is computationally highly demanding. The goal of this study was to develop a fast surrogate model of the tibiofemoral (TF) contact in a total knee replacement (TKR) model and apply it to force-dependent kinematic (FDK) simulations of activities of daily living (ADLs). Multiple domains were populated with sample points from the reference TKR contact model, based on reference simulations and design-of-experiments. Artificial neural networks (ANN) learned the relationship between TF pose and loads from the medial and lateral sides of the TKR implant. Normal and right-turn gait, rising-from-a-chair, and a squat were simulated using both surrogate and reference contact models. Compared to the reference contact model, the surrogate contact model predicted TF forces with a root-mean-square error (RMSE) lower than 10 N and TF moments lower than 0.3 N·m over all simulated activities. Secondary knee kinematics were predicted with RMSE lower than 0.2 mm and 0.2 deg. Simulations that used the surrogate contact model ran on average three times faster than those using the reference model, allowing the simulation of a full gait cycle in 4.5 min. This modeling approach proved fast and accurate enough to perform extensive parametric analyses, such as simulating subject-specific variations and surgical-related factors in TKR.
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August 2017
Research-Article
Evaluation of a Surrogate Contact Model in Force-Dependent Kinematic Simulations of Total Knee Replacement
Marco A. Marra,
Marco A. Marra
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Marco.Marra@radboudumc.nl
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Marco.Marra@radboudumc.nl
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Michael S. Andersen,
Michael S. Andersen
Aalborg University,
Department of Mechanical and Manufacturing
Engineering,
Fibigerstraede 16,
Aalborg DK-9220, Denmark
e-mail: msa@m-tech.aau.dk
Department of Mechanical and Manufacturing
Engineering,
Fibigerstraede 16,
Aalborg DK-9220, Denmark
e-mail: msa@m-tech.aau.dk
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Bart F. J. M. Koopman,
Bart F. J. M. Koopman
Department of Biomechanical Engineering,
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: h.f.j.m.koopman@utwente.nl
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: h.f.j.m.koopman@utwente.nl
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Dennis Janssen,
Dennis Janssen
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Dennis.Janssen@radboudumc.nl
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Dennis.Janssen@radboudumc.nl
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Nico Verdonschot
Nico Verdonschot
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands;
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands;
Department of Biomechanical Engineering,
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: Nico.Verdonschot@radboudumc.nl
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: Nico.Verdonschot@radboudumc.nl
Search for other works by this author on:
Marco A. Marra
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Marco.Marra@radboudumc.nl
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Marco.Marra@radboudumc.nl
Michael S. Andersen
Aalborg University,
Department of Mechanical and Manufacturing
Engineering,
Fibigerstraede 16,
Aalborg DK-9220, Denmark
e-mail: msa@m-tech.aau.dk
Department of Mechanical and Manufacturing
Engineering,
Fibigerstraede 16,
Aalborg DK-9220, Denmark
e-mail: msa@m-tech.aau.dk
Michael Damsgaard
Bart F. J. M. Koopman
Department of Biomechanical Engineering,
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: h.f.j.m.koopman@utwente.nl
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: h.f.j.m.koopman@utwente.nl
Dennis Janssen
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Dennis.Janssen@radboudumc.nl
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands
e-mail: Dennis.Janssen@radboudumc.nl
Nico Verdonschot
Orthopaedic Research Laboratory,
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands;
Radboud Institute for Health Sciences,
Radboud University Medical Center,
P. O. Box 9101,
Nijmegen 6500 HB, The Netherlands;
Department of Biomechanical Engineering,
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: Nico.Verdonschot@radboudumc.nl
University of Twente,
P. O. Box 217,
Enschede 7500 AE, The Netherlands
e-mail: Nico.Verdonschot@radboudumc.nl
1Corresponding author.
Manuscript received June 24, 2016; final manuscript received April 24, 2017; published online June 7, 2017. Assoc. Editor: Paul Rullkoetter.
J Biomech Eng. Aug 2017, 139(8): 081001 (10 pages)
Published Online: June 7, 2017
Article history
Received:
June 24, 2016
Revised:
April 24, 2017
Citation
Marra, M. A., Andersen, M. S., Damsgaard, M., Koopman, B. F. J. M., Janssen, D., and Verdonschot, N. (June 7, 2017). "Evaluation of a Surrogate Contact Model in Force-Dependent Kinematic Simulations of Total Knee Replacement." ASME. J Biomech Eng. August 2017; 139(8): 081001. https://doi.org/10.1115/1.4036605
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