Joint contact forces measured with instrumented knee implants have not only revealed general patterns of joint loading but also showed individual variations that could be due to differences in anatomy and joint kinematics. Musculoskeletal human models for dynamic simulation have been utilized to understand body kinetics including joint moments, muscle tension, and knee contact forces. The objectives of this study were to develop a knee contact model which can predict knee contact forces using an inverse dynamics-based optimization solver and to investigate the effect of joint constraints on knee contact force prediction. A knee contact model was developed to include 32 reaction force elements on the surface of a tibial insert of a total knee replacement (TKR), which was embedded in a full-body musculoskeletal model. Various external measurements including motion data and external force data during walking trials of a subject with an instrumented knee implant were provided from the Sixth Grand Challenge Competition to Predict in vivo Knee Loads. Knee contact forces in the medial and lateral portions of the instrumented knee implant were also provided for the same walking trials. A knee contact model with a hinge joint and normal alignment could predict knee contact forces with root mean square errors (RMSEs) of 165 N and 288 N for the medial and lateral portions of the knee, respectively, and coefficients of determination (R2) of 0.70 and −0.63. When the degrees-of-freedom (DOF) of the knee and locations of leg markers were adjusted to account for the valgus lower-limb alignment of the subject, RMSE values improved to 144 N and 179 N, and R2 values improved to 0.77 and 0.37, respectively. The proposed knee contact model with subject-specific joint model could predict in vivo knee contact forces with reasonable accuracy. This model may contribute to the development and improvement of knee arthroplasty.
Issue Section:
Research Papers
References
1.
Hewett
, T. E.
, Myer
, G. D.
, Ford
, K. R.
, Heidt
, R. S.
, Colosimo
, A. J.
, McLean
, S. G.
, and Succop
, P.
, 2005
, “Biomechanical Measures of Neuromuscular Control and Valgus Loading of the Knee Predict Anterior Cruciate Ligament Injury Risk in Female Athletes a Prospective Study
,” Am. J. Sports Med.
, 33
(4
), pp. 492
–501
.2.
Andriacchi
, T. P.
, Mündermann
, A.
, Smith
, R. L.
, Alexander
, E. J.
, Dyrby
, C. O.
, and Koo
, S.
, 2004
. “A Framework for the In Vivo Pathomechanics of Osteoarthritis at the Knee
,” Ann. Biomed. Eng.
, 32
(3
), pp. 447
–457
.3.
Wimmer
, M. A.
, and Andriacchi
, T. P.
, 1997
, “Tractive Forces During Rolling Motion of the Knee: Implications for Wear in Total Knee Replacement
,” J. Biomech.
, 30
(2
), pp. 131
–137
.4.
Kellett
, C. F.
, Short
, A.
, Price
, A.
, Gill
, H. S.
, and Murray
, D. W.
, 2004
, “In Vivo Measurement of Total Knee Replacement Wear
,” Knee
, 11
(3
), pp. 183
–187
.5.
Walter
, J. P.
, D'Lima
, D. D.
, Colwell
, C. W.
, and Fregly
, B. J.
, 2010
, “Decreased Knee Adduction Moment Does Not Guarantee Decreased Medial Contact Force during Gait
,” J. Orthop. Res.
, 28
(10
), pp. 1348
–1354
.6.
Bei
, Y.
, and Fregly
, B. J.
, 2004
, “Multibody Dynamic Simulation of Knee Contact Mechanics
,” Med. Eng. Phys.
, 26
(9
), pp. 777
–789
.7.
Banks
, S. A.
, Markovich
, G. D.
, and Hodge
, W. A.
, 1997
, “In Vivo Kinematics of Cruciate-Retaining and -Substituting Knee Arthroplasties
,” J. Arthroplasty
, 12
(3
), pp. 297
–304
.8.
D'Lima
, D. D.
, Steklov
, N.
, Patil
, S.
, and Colwell
, C. W.
, Jr., 2008
, “The Mark Coventry Award: In Vivo Knee Forces During Recreation and Exercise After Knee Arthroplasty
,” Clin. Orthop. Relat. Res.
, 466
(11
), pp. 2605
–2611
.9.
Bergmann
, G.
, Deuretzbacher
, G.
, Heller
, M.
, Graichen
, F.
, Rohlmann
, A.
, Strauss
, J.
, and Duda
, G. N.
, 2001
, “Hip Contact Forces and Gait Patterns From Routine Activities
,” J. Biomech.
, 34
(7
), pp. 859
–871
.10.
Damm
, P.
, Graichen
, F.
, Rohlmann
, A.
, Bender
, A.
, and Bergmann
, G.
, 2010
, “Total Hip Joint Prosthesis for In Vivo Measurement of Forces and Moments
,” Med. Eng. Phys.
, 32
(1
), pp. 95
–100
.11.
Wilke
, H. J.
, Neef
, P.
, Caimi
, M.
, Hoogland
, T.
, and Claes
, L. E.
, 1999
, “New In Vivo Measurements of Pressures in the Intervertebral Disc in Daily Life
,” Spine
, 24
(8
), pp. 755
–762
.12.
Sato
, K.
, Kikuchi
, S.
, and Yonezawa
, T.
, 1999
, “In Vivo Intradiscal Pressure Measurement in Healthy Individuals and in Patients With Ongoing Back Problems
,” Spine
, 24
(23
), pp. 2468
–2474
.13.
D'Lima
, D. D.
, Townsend
, C. P.
, Arms
, S. W.
, Morris
, B. A.
, and Colwell
, C. W.
, 2005
, “An Implantable Telemetry Device to Measure Intra-Articular Tibial Forces
,” J. Biomech.
, 38
(2
), pp. 299
–304
.14.
Kutzner
, I.
, Heinlein
, B.
, Graichen
, F.
, Bender
, A.
, Rohlmann
, A.
, Halder
, A.
, and Bergmann
, G.
, 2010
, “Loading of the Knee Joint During Activities of Daily Living Measured In Vivo in Five Subjects
,” J. Biomech.
, 43
(11
), pp. 2164
–2173
.15.
Kia
, M.
, Stylianou
, A. P.
, and Guess
, T. M.
, 2014
, “Evaluation of a Musculoskeletal Model With Prosthetic Knee Through Six Experimental Gait Trials
,” Med. Eng. Phys.
, 36
(3
), pp. 335
–344
.16.
Thelen
, D. G.
, Choi
, K. W.
, and Schmitz
, A. M.
, 2014
, “Co-Simulation of Neuromuscular Dynamics and Knee Mechanics During Human Walking
,” ASME J. Biomech. Eng.
, 136
(2
), p. 021033
.17.
Hast
, M. W.
, and Piazza
, S. J.
, 2013
, “Dual-Joint Modeling for Estimation of Total Knee Replacement Contact Forces During Locomotion
,” ASME J. Biomech. Eng.
, 135
(2
), p. 021013
.18.
Marra
, M. A.
, Vanheule
, V.
, Fluit
, R.
, Koopman
, B. H.
, Rasmussen
, J.
, Verdonschot
, N.
, and Andersen
, M. S.
, 2015
, “A Subject-Specific Musculoskeletal Modeling Framework to Predict In Vivo Mechanics of Total Knee Arthroplasty
,” ASME J. Biomech. Eng.
, 137
(2
), p. 020904
.19.
Chen
, Z.
, Wang
, L.
, Liu
, Y.
, He
, J.
, Lian
, Q.
, Li
, D.
, and Jin
, Z.
, 2015
, “Effect of Component Mal-Rotation on Knee Loading in Total Knee Arthroplasty Using Multi-Body Dynamics Modeling Under a Simulated Walking Gait
,” J. Orthop. Res.
, 33
(9
), pp. 1287
–1296
.20.
Fregly
, B. J.
, Besier
, T. F.
, Lloyd
, D. G.
, Delp
, S. L.
, Banks
, S. A.
, Pandy
, M. G.
, and D'Lima
, D. D.
, 2012
, “Grand Challenge Competition to Predict In Vivo Knee Loads
,” J. Orthop. Res.
, 30
(4
), pp. 503
–513
.21.
Delp
, S. L.
, Anderson
, F. C.
, Arnold
, A. S.
, Loan
, P.
, Habib
, A.
, John
, C. T.
, Guendelman
, E.
, and Thelen
, D. G.
, 2007
, “OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement
,” IEEE Trans. Biomed. Eng.
, 54
(11
), pp. 1940
–1950
.22.
Jung
, Y.
, Jung
, M.
, Lee
, K.
, and Koo
, S.
, 2014
, “
Ground Reaction Force Estimation Using an Insole-Type Pressure Mat and Joint Kinematics During Walking
,” J. Biomech.
, 47
(11
), pp. 2693
–2699
.23.
Simtk,
2015
, “Grand Challenge Competition to Predict In Vivo Knee Loads
,” Simbios, NIH Center for Biomedical Computation at Stanford, Stanford, CA, accessed July 22, 2014, https://simtk.org/project/xml/downloads.xml?group_id=41324.
Damsgaard
, M.
, Rasmussen
, J.
, Christensen
, S. T.
, Surma
, E.
, and de Zee
, M.
, 2006
, “Analysis of Musculoskeletal Systems in the AnyBody Modeling System
,” Simul. Model. Pract. Theory
, 14
(8
), pp. 1100
–1111
.25.
Horsman
, M. K.
, Koopman
, H. F. J. M.
, Van der Helm
, F. C. T.
, Prosé
, L. P.
, and Veeger
, H. E. J.
, 2007
, “Morphological Muscle and Joint Parameters for Musculoskeletal Modelling of the Lower Extremity
,” Clin. Biomech.
, 22
(2
), pp. 239
–247
.26.
Crowninshield
, R. D.
, and Brand
, R. A.
, 1981
, “A Physiologically Based Criterion of Muscle Force Prediction in Locomotion
,” J. Biomech.
, 14
(11
), pp. 793
–801
.27.
Erdemir
, A.
, McLean
, S.
, Herzog
, W.
, and van den Bogert
, A. J.
, 2007
, “Model-Based Estimation of Muscle Forces Exerted During Movements
,” Clin. Biomech.
, 22
(2
), pp. 131
–154
.28.
Phan
, C. B.
, and Koo
, S.
, 2015
, “Predicting Anatomical Landmarks and Bone Morphology of the Femur Using Local Region Matching
,” Int. J. Comput. Assist. Radiol. Surg.
, 10
(11
), pp. 1711
–1719
.29.
Du
, S.
, Zheng
, N.
, Xiong
, L.
, Ying
, S.
, and Xue
, J.
, 2010
, “Scaling Iterative Closest Point Algorithm for Registration of m–D Point Sets
,” J. Vis. Commun. Image Represent.
, 21
(5
), pp. 442
–452
.30.
Wu
, G.
, Siegler
, S.
, Allard
, P.
, Kirtley
, C.
, Leardini
, A.
, Rosenbaum
, D.
, and Stokes
, I.
, 2002
, “ISB Recommendation on Definitions of Joint Coordinate System of Various Joints for the Reporting of Human Joint Motion—Part I: Ankle, Hip, and Spine
,” J. Biomech.
, 35
(4
), pp. 543
–548
.31.
Rasmussen
, J.
, Zee
, M. D.
, Damsgaard
, M.
, Christensen
, S. T.
, Marek
, C.
, and Siebertz
, K.
, 2005
, “A General Method for Scaling Musculoskeletal Models
,” 2005 International Symposium on Computer Simulation in Biomechanics
, Cleveland, OH, July 28–30.32.
Andersen
, M. S.
, Damsgaard
, M.
, and Rasmussen
, J.
, 2009
, “Kinematic Analysis of Over-Determinate Biomechanical Systems
,” Comput. Methods Biomech. Biomed. Eng.
, 12
(4
), pp. 371
–384
.33.
Hurwitz
, D. E.
, Sumner
, D. R.
, Andriacchi
, T. P.
, and Sugar
, D. A.
, 1998
, “Dynamic Knee Loads During Gait Predict Proximal Tibial Bone Distribution
,” J. Biomech.
, 31
(5
), pp. 423
–430
.34.
Halder
, A.
, Kutzner
, I.
, Graichen
, F.
, Heinlein
, B.
, Beier
, A.
, and Bergmann
, G.
, 2012
, “Influence of Limb Alignment on Mediolateral Loading in Total Knee Replacement
,” J. Bone. Joint. Surg.
, 94
(11
), pp. 1023
–1029
.35.
Kinney
, A. L.
, Besier
, T. F.
, D'Lima
, D. D.
, and Fregly
, B. J.
, 2013
, “Update on Grand Challenge Competition to Predict In Vivo Knee Loads
,” ASME J. Biomech. Eng.
, 135
(2
), p. 021012
.36.
Kim
, Y.-H.
, Park
, W.-M.
, and Phuong
, B. T. T.
, 2010
, “Effect of Joint Center Location on In-Vivo Joint Contact Forces During Walking
,” ASME
Paper No. SBC2010-19353. 37.
Manal
, K.
, and Buchanan
, T. S.
, 2013
, “An Electromyogram-Driven Musculoskeletal Model of the Knee to Predict In Vivo Joint Contact Forces During Normal and Novel Gait Patterns
,” ASME J. Biomech. Eng.
, 135
(2
), p. 021014
.38.
Lundberg
, H. J.
, Knowlton
, C.
, and Wimmer
, M. A.
, 2013
, “Fine Tuning Total Knee Replacement Contact Force Prediction Algorithms Using Blinded Model Validation
,” ASME J. Biomech. Eng.
, 135
(2
), p. 021015
.39.
Redert
, A.
, Kaptein
, B.
, Reinders
, M.
, Van den Eelaart
, I.
, and Hendriks
, E.
, 1999
, “Extraction of Semantic 3D Models of Human Faces From Stereoscopic Image Sequences
,” Acta Stereol.
, 18
(2
), pp. 255
–264
.40.
Pellikaan
, P.
, van der Krogt
, M. M.
, Carbone
, V.
, Fluit
, R.
, Vigneron
, L. M.
, Van Deun
, J.
, and Koopman
, H. F. J. M.
, 2014
, “Evaluation of a Morphing Based Method to Estimate Muscle Attachment Sites of the Lower Extremity
,” J. Biomech.
, 47
(5
), pp. 1144
–1150
.41.
Chen
, Z.
, Zhang
, X.
, Ardestani
, M. M.
, Wang
, L.
, Liu
, Y.
, Lian
, Q.
, He
, J.
, Li
, D.
, and Jin
, Z.
, 2014
, “Prediction of In Vivo Joint Mechanics of an Artificial Knee Implant Using Rigid Multi-Body Dynamics With Elastic Contacts
,” Proc. Inst. Mech. Eng., Part H
, 228
(6
), pp. 564
–575
.42.
Asano
, T.
, Akagi
, M.
, and Nakamura
, T.
, 2005
, “The Functional Flexion–Extension Axis of the Knee Corresponds to the Surgical Epicondylar Axis: In Vivo Analysis Using a Biplanar Image-Matching Technique
,” J. Arthroplasty
, 20
(8
), pp. 1060
–1067
.43.
Akbarshahi
, M.
, Schache
, A. G.
, Fernandez
, J. W.
, Baker
, R.
, Banks
, S.
, and Pandy
, M. G.
, 2010
, “Non-Invasive Assessment of Soft-Tissue Artifact and Its Effect on Knee Joint Kinematics During Functional Activity
,” J. Biomech.
, 43
(7
), pp. 1292
–1301
.44.
Liu
, W.
, and Maitland
, M. E.
, 2000
, “The Effect of Hamstring Muscle Compensation for Anterior Laxity in the ACL-Deficient Knee During Gait
,” J. Biomech.
, 33
(7
), pp. 871
–879
.45.
Walter
, J. P.
, Kinney
, A. L.
, Banks
, S. A.
, D'Lima
, D. D.
, Besier
, T. F.
, Lloyd
, D. G.
, and Fregly
, B. J.
, 2014
, “Muscle Synergies May Improve Optimization Prediction of Knee Contact Forces During Walking
,” ASME J. Biomech. Eng.
, 136
(2
), p. 021031
.46.
D'Lima
, D. D.
, Patil
, S.
, Steklov
, N.
, and Colwell
, C. W.
, Jr., 2007
, “An ABJS Best Paper: Dynamic Intraoperative Ligament Balancing for Total Knee Arthroplasty
,” Clin. Orthop. Relat. Res.
, 463
, pp. 208
–212
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