Although microdamage is known to accumulate in trabecular bone with overloading and aging, the tissue-level stresses and strains associated with local bone failure are not well known. Local correlation of microdamage with microstructural stresses and strains requires methods to accurately register histological sections with micro-computed tomography (micro-CT) based finite element models. In addition, the resolution of correlation (i.e., grid size) selected for analysis may affect the observed results. Therefore, an automated, repeatable, and accurate image registration algorithm was developed to determine the range of local stresses and strains associated with microdamage initiation. Using a two-dimensional rigid registration algorithm, bone structures from histology and micro-CT imaging were aligned. Once aligned, microdamaged regions were spatially correlated with local stresses and strains obtained from micro-CT based finite element analysis. Using this more sophisticated registration technique, we were able to analyze the effects of varying spatial grid resolution on local stresses and strains initiating microdamage. The results indicated that grid refinement to the individual pixel level (pixel-by-pixel method) more precisely defined the range of microdamage initiation compared to manually selected individual damaged and undamaged trabeculae. Using the pixel-by-pixel method, we confirmed that trabecular bone from younger cows sustained higher local strains prior to microdamage initiation compared to older bone.
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June 2011
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Spatial Correlations of Trabecular Bone Microdamage with Local Stresses and Strains Using Rigid Image Registration
Srinidhi Nagaraja,
Srinidhi Nagaraja
Woodruff School of Mechanical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332, Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
, Atlanta, GA 30332
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Oskar Skrinjar,
Oskar Skrinjar
Coulter Department of Biomedical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332
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Robert E. Guldberg
Robert E. Guldberg
Woodruff School of Mechanical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
, Atlanta, GA 30332; Coulter Department of Biomedical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332 e-mail:
Search for other works by this author on:
Srinidhi Nagaraja
Woodruff School of Mechanical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332, Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
, Atlanta, GA 30332
Oskar Skrinjar
Coulter Department of Biomedical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332
Robert E. Guldberg
Woodruff School of Mechanical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology
, Atlanta, GA 30332; Coulter Department of Biomedical Engineering, Georgia Institute of Technology
, Atlanta, GA 30332 e-mail: J Biomech Eng. Jun 2011, 133(6): 064502 (5 pages)
Published Online: June 14, 2011
Article history
Received:
December 26, 2008
Revised:
July 1, 2009
Posted:
May 5, 2011
Published:
June 14, 2011
Online:
June 14, 2011
Citation
Nagaraja, S., Skrinjar, O., and Guldberg, R. E. (June 14, 2011). "Spatial Correlations of Trabecular Bone Microdamage with Local Stresses and Strains Using Rigid Image Registration." ASME. J Biomech Eng. June 2011; 133(6): 064502. https://doi.org/10.1115/1.4004164
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