Current brain deformation models have predominantly reflected solid constitutive relationships generated from empirical ex vivo data and have largely overlooked interstitial hydrodynamic effects. In the context of a technique to update images intraoperatively for image-guided neuronavigation, we have developed and quantified the deformation characteristics of a three-dimensional porous media finite element model of brain deformation in vivo. Results have demonstrated at least 75–85 percent predictive capability, but have also indicated that interstitial hydrodynamics are important. In this paper we investigate interstitial pressure transient behavior in brain tissue when subjected to an acute surgical load consistent with neurosurgical events. Data are presented from three in vivo porcine experiments where subsurface tissue deformation and interhemispheric pressure gradients were measured under conditions of an applied mechanical deformation and then compared to calculations with our three-dimensional brain model. Results demonstrate that porous-media consolidation captures the hydraulic behavior of brain tissue subjected to comparable surgical loads and that the experimental protocol causes minimal trauma to porcine brain tissue. Working values for hydraulic conductivity of white and gray matter are also reported and an assessment of transient pressure gradient effects with respect to deformation is provided. [S0148-0731(00)00804-9]
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August 2000
Technical Papers
In Vivo Modeling of Interstitial Pressure in the Brain Under Surgical Load Using Finite Elements
Michael I. Miga, Research Assistant Professor,,
Michael I. Miga, Research Assistant Professor,
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
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Keith D. Paulsen,
Keith D. Paulsen
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
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P. Jack Hoopes,
P. Jack Hoopes
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
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Francis E. Kennedy,
Francis E. Kennedy
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
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Alex Hartov,
Alex Hartov
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
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David W. Roberts
David W. Roberts
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
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Michael I. Miga, Research Assistant Professor,
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Keith D. Paulsen
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
P. Jack Hoopes
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
Francis E. Kennedy
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Alex Hartov
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
David W. Roberts
Dartmouth Hitchcock Medical Center, Lebanon, NH 03766
Norris Cotton Cancer Center, Lebanon, NH 03766
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division March 9, 1999; revised manuscript received March 22, 2000. Associate Technical Editor: R. C. Haut.
J Biomech Eng. Aug 2000, 122(4): 354-363 (10 pages)
Published Online: March 22, 2000
Article history
Received:
March 9, 1999
Revised:
March 22, 2000
Citation
Miga, M. I., Paulsen , K. D., Hoopes, P. J., Kennedy, F. E., Hartov, A., and Roberts, D. W. (March 22, 2000). "In Vivo Modeling of Interstitial Pressure in the Brain Under Surgical Load Using Finite Elements ." ASME. J Biomech Eng. August 2000; 122(4): 354–363. https://doi.org/10.1115/1.1288207
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